the antiproliferative effects of petroleum ether extract of artemisia aucheri on human cancerous cell lines
نویسندگان
چکیده
different species of artemisia (asteraceae) have shown to exhibit antitumor activity. the aim of this study was to identify the antiproliferative effect of artemisia aucheri boiss (a.aucheri) from iran on cultured human cancer cells. aerial parts of artemisia aucheri boiss. were collected from chahar bagh region (2150 m altitude, sep. 2011),golestan province, iran.the dried powdered aerial parts of a.aucheri were extracted with petroleum ether (40-60), dichloromethane, ethyl acetate, ethanol and ethanol-water (1:1 v/v), respectively.for biological investigation different concentrations of extracts were added to cultured cells and incubated for 24 h. 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide (mtt) assay was employed to assess the cell viability.in addition,morphological changes of cells were assayed using phase contrast inverted microscope. different extracts exert various growth inhibitory effects. in case of sknmc,mcf-7 and a2780 cells, pertroleum ether extracts (ic 50 values: 21.0, 26.0 and 28.0 µg/ml, respectively) showed the highest growth inhibitory effects. dichloromethane extracts showed ic 50 values: 27.0, 35.0 and 55.0 µg/ml, respectively.this study shows the antiproliferative effects of a.aucheri petroleum ether extract on malignant cell lines. thus, may be considered as a promising chemotherapeutic agent in cancer treatment.
منابع مشابه
Cytotoxic and Apoptogenic Sesquiterpenoids from the Petroleum Ether Extract of Artemisia aucheri Aerial Parts
Different types of Artemisia aucheri extracts were reported to have various biological activities including a cytotoxic effect on some cancer cell lines. We investigated the antiproliferative activity of isolated sesquiterpenoids from petroleum ether extract of Artemisia aucheri (A. aucheri)aerial parts on SK-N-MC, MCF-7, and A2780 cell lines. Phytochemicals from the petroleum ether cold macera...
متن کاملCytotoxic and Apoptogenic Sesquiterpenoids from the Petroleum Ether Extract of Artemisia aucheri Aerial Parts
Different types of Artemisia aucheri extracts were reported to have various biological activities including a cytotoxic effect on some cancer cell lines. We investigated the antiproliferative activity of isolated sesquiterpenoids from petroleum ether extract of Artemisia aucheri (A. aucheri)aerial parts on SK-N-MC, MCF-7, and A2780 cell lines. Phytochemicals from the petroleum ether cold macera...
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عنوان ژورنال:
journal of reports in pharmaceutical sciencesجلد ۲، شماره ۲، صفحات ۱۵۰-۱۵۵
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